FITC标记的白介素21受体抗体
产品名称： FITC标记的白介素21受体抗体
英文名称： Anti-IL21R/FITC
产品编号： HZ-2622R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-IL21R/FITC Conjugated antibody
FITC标记的白介素21受体抗体
| 英文名称 | Anti-IL21R/FITC |
| 中文名称 | FITC标记的白介素21受体抗体 |
| 别 名 | IL 21R; IL-21R; IL21 Receptor; IL21R; Interleukin 21 receptor; MGC10967; NILR; IL21R_HUMAN; CD360; IL-21 receptor; IL21 Receptor; Interleukin-21 receptor; Novel interleukin receptor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from humna IL-21R |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] Function: This is a receptor for interleukin-21. Subunit: Heterodimer with the common gamma subunit. Associates with JAK1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen. Post-translational modifications: C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains. Database links: Entrez Gene: 50615 Human Entrez Gene: 60504 Mouse Entrez Gene: 308977 Rat Omim: 605383 Human SwissProt: Q9HBE5 Human SwissProt: Q9JHX3 Mouse SwissProt: Q5EBB1 Rat Unigene: 210546 Human Unigene: 155643 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白是白细胞介素21（IL21）的细胞因子受体。它属于I型细胞因子受体，并且已被证明形成具有共同γ链的异源二聚体受体复合物，该受体亚基还由白介素2, 4, 7、9和15的受体共享。该受体转导IL21的生长促进信号，并且对T细胞、B细胞和自然杀伤（NK）细胞的增殖和分化具有重要意义。该受体的配体结合导致多个下游信号分子的激活，包括JAK1、JAK3、STAT1和STAT3。敲除小鼠中类似基因的研究表明该基因在调节免疫球蛋白产生中发挥作用。已经描述了三种交替剪接转录变体。[ RefSeq，JUL 2010 ]