FITC标记的蛋白激酶A锚定蛋白6抗体
产品名称： FITC标记的蛋白激酶A锚定蛋白6抗体
英文名称： Anti-AKAP6/FITC
产品编号： HZ-7904R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-AKAP6/FITC Conjugated antibody
FITC标记的蛋白激酶A锚定蛋白6抗体
| 英文名称 | Anti-AKAP6/FITC |
| 中文名称 | FITC标记的蛋白激酶A锚定蛋白6抗体 |
| 别 名 | A kinase (PRKA) anchor protein 6; A kinase anchor protein 100; A kinase anchor protein 100 kDa; A kinase anchor protein 6; ADAP 100; ADAP 6; ADAP100; ADAP6; AKAP 100; AKAP 6; AKAP100; Human A kinase anchor protein AKAP100; KIAA0311; mAKAP; PRKA 6; PRKA6; Protein kinase A anchoring protein 6; AKAP6_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 257kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AKAP6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The A Kinase Anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP6 is a member of the AKAP family. It is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. Subunit: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79. Subcellular Location: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences. Tissue Specificity: Highly expressed in cardiac and skeletal muscle, followed by brain. Similarity: Contains 2 spectrin repeats. Database links: UniProtKB/Swiss-Prot: Q13023.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
A激酶锚定蛋白（AkAPS）是一组结构多样的蛋白质，具有与蛋白激酶A（PKA）的调节亚基结合的共同功能，并将全酶限制在细胞内的离散位置。AkAP6是AKAP家族的成员。它在各种脑区和心脏和骨骼肌中高表达。它主要定位于肌浆网和核膜，并参与PKA向核膜或肌浆网的锚定。