FITC标记的细胞表面趋化因子受体2抗体
产品名称： FITC标记的细胞表面趋化因子受体2抗体
英文名称： Anti-CXCR2/FITC
产品编号： HZ-4836R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CXCR2/FITC Conjugated antibody
FITC标记的细胞表面趋化因子受体2抗体
| 产品编号 | bs-4836R-FITC |
| 英文名称 | Anti-CXCR2/FITC |
| 中文名称 | FITC标记的细胞表面趋化因子受体2抗体 |
| 别 名 | CXC-chemokine receptor 2; CD 182; CD182; CD182 antigen; CDw128b; Chemokine (CXC) receptor 2; CMKAR2; CXCR 2; CXC R2; CXC-R2; CXCR2_HUMAN; C-X-C chemokine receptor type 2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 G蛋白偶联受体 细胞分化 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CXCR2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]. Function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylated upon ligand binding; which is required for desensitization. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 3579 Human Entrez Gene: 12765 Mouse Entrez Gene: 29385 Rat Omim: 146928 Human SwissProt: P25025 Human SwissProt: P35343 Mouse SwissProt: P35407 Rat Unigene: 846 Human Unigene: 234466 Mouse Unigene: 90347 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是G-蛋白偶联受体家族的成员。这种蛋白是白细胞介素8（IL8）的受体。它与高亲和力的IL8结合，并通过G蛋白激活的第二信使系统转导信号。该受体还与趋化因子（C-X-Cytof）配体1（CXCL1/MGSA）结合，该蛋白具有黑色素瘤生长刺激活性，并且已被证明是血清依赖性黑色素瘤细胞生长所需的主要成分。这种受体介导中性粒细胞迁移到炎症部位。IL8在小肠微血管内皮细胞中的血管生成作用是由该受体介导的。敲除小鼠的研究表明，该受体控制少突胶质细胞前体在脊髓发育中的定位，阻止其迁移。该基因，IL8RA，编码另一个高亲和力IL8受体的基因，以及IL8RBP，IL8Rb的假基因，在映射到染色体2q33-Q36的区域中形成基因簇。选择性地剪接变异体，编码相同的蛋白质，已被鉴定。[ RefSeq，NOV 2009 ]提供。