MAP2K1 polyclonal antibody
产品名称： MAP2K1 polyclonal antibody
英文名称： MAP2K1 polyclonal antibody
产品编号： PAB3172
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAP2K1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MAP2K1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA.J Neurochem. 2003 Jul;86(1):136-42.
- 2.
- p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.
Li SP, Junttila MR, Han J, Kahari VM, Westermarck J.Cancer Res. 2003 Jul 1;63(13):3473-7.
- 3.
- MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival.
Zheng B, Fiumara P, Li YV, Georgakis G, Snell V, Younes M, Vauthey JN, Carbone A, Younes A.Blood. 2003 Aug 1;102(3):1019-27. Epub 2003 Apr 10.
- Applications
- Western Blot
- Western blot analysis of MAP2K1 polyclonal antibody (Cat # PAB3172) in A-375 cell lysate (Lane 1) and mouse brain tissue lysate (Lane 2) . MAP2K1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MAP2K1 polyclonal antibody (Cat # PAB3172) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 5604
- Protein Accession#:
- Q02750
- Gene Name:
- MAP2K1
- Gene Alias:
- MAPKK1,MEK1,MKK1,PRKMK1
- Gene Description:
- mitogen-activated protein kinase kinase 1
- Omim ID:
- 176872
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq
- Other Designations:
- protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
- Gene Pathway
- Acute myeloid leukemia
- B cell receptor signaling pathway
- Bladder cancer
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Dorso-ventral axis formation
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prion diseases
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- T cell receptor signaling pathway
- Thyroid cancer
- Toll-like receptor signaling pathway
- Vascular smooth muscle contraction
- VEGF signaling pathway
- Related Disease
- Abnormalities, Multiple
- Adenocarcinoma
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cognition Disorders
- Developmental Disabilities
- Ectodermal Dysplasia
- Genetic Predisposition to Disease
- Glioma
- Heart Defects, Congenital
- LEOPARD Syndrome
- Lung Neoplasms
- Mental Retardation
- Noonan Syndrome
- Pancreatic Neoplasms
- Skin Abnormalities
- Syndrome