ABCB11 polyclonal antibody
产品名称： ABCB11 polyclonal antibody
英文名称： ABCB11 polyclonal antibody
产品编号： PAB4697
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ABCB11.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ABCB11.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels.
Chen HL, Chang PS, Hsu HC, Ni YH, Hsu HY, Lee JH, Jeng YM, Shau WY, Chang MH.J Pediatr. 2002 Jan;140(1):119-24.
- 2.
- Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.
Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y.J Hum Genet. 2002;47(1):38-50.
- 3.
- A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis.
Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Nemeth A, Pawlowska J, Baker A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ.Nat Genet. 1998 Nov;20(3):233-8.
- Applications
- Western Blot (Tissue lysate)
- The ABCB11 polyclonal antibody (Cat # PAB4697) is used in Western blot to detect ABCB11 in mouse liver tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ABCB11 polyclonal antibody (Cat # PAB4697) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 8647
- Protein Accession#:
- O95342
- Gene Name:
- ABCB11
- Gene Alias:
- ABC16,BSEP,PFIC-2,PFIC2,PGY4,SPGP
- Gene Description:
- ATP-binding cassette, sub-family B (MDR/TAP), member 11
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq
- Other Designations:
- ABC member 16, MDR/TAP subfamily,bile salt export pump,progressive familial intrahepatic cholestasis 2,sister p-glycoprotein
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Breast cancer
- Carcinoma, Hepatocellular
- Cardiovascular Diseases
- Cholangitis, Sclerosing
- Cholestasis
- Cholestasis, Intrahepatic
- Diabetes Mellitus, Type 2
- Edema
- Esophageal Neoplasms
- Gallstones
- Genetic Predisposition to Disease
- Hearing Loss
- Hyperlipidemias
- Kidney Failure, Chronic
- Liver Cirrhosis, Biliary
- Liver Diseases
- Liver Neoplasms
- Lung Neoplasms