FITC标记的流感病毒H3N2血凝素抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的流感病毒H3N2血凝素抗体

FITC标记的流感病毒H3N2血凝素抗体

商家询价

产品名称： FITC标记的流感病毒H3N2血凝素抗体

英文名称： Anti-H3N2 hemagglutinin/FITC

产品编号： HZ-2137R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-H3N2 hemagglutinin/FITC Conjugated antibody

FITC标记的流感病毒H3N2血凝素抗体

 

产品编号 bs-2137R-FITC
英文名称 Anti-H3N2 hemagglutinin/FITC
中文名称 FITC标记的流感病毒H3N2血凝素抗体
别    名 HA; Influenza A virus H3N2; hemagglutinin; H3N2; H3N2 hemagglutinin; HEMA_I68A0; Hemagglutinin HA1 chain; Hemagglutinin HA2 chain.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  信号转导  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Influenza A virus H3N2
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from H3N2 hemagglutinin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Hemagglutinin (HA) is a class I viral fusion protein from Influenza virus. It is a major glycoprotein, comprising over 80% of the envelope proteins present in the virus particle. HA binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell, and is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. The extent of infection into host organism is determined by HA. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoproteases secreted by the bronchial epithelial cells. The HA protein is a homotrimer of disulfide-linked HA1-HA2. It also plays a major role in the determination of host range restriction and virulence. Genetic variation of hemagglutinin and/or neuraminidase genes results in the emergence of new influenza strains.

Function:
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Subunit:
Homotrimer of disulfide-linked HA1-HA2.

Subcellular Location:
Cell membrane; apical cell membrane; single-pass type I membrane protein.

Post-translational modifications:
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells. Palmitoylated (By similarity).

Similarity:
Belongs to the influenza viruses hemagglutinin family.

Database links:
UniProtKB/Swiss-Prot: P03437.1 
GenBank: AGB84854.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

Hemagglutinin（HA）是一种来自流感病毒的I类病毒融合蛋白。它是一种主要的糖蛋白，包含超过80%的存在于病毒颗粒中的包膜蛋白。HA与细胞表面含有唾液酸的受体结合，使病毒颗粒附着于细胞，并通过介导内吞病毒颗粒膜与内涵体MEM的融合，将病毒渗透到细胞细胞质中。布兰。感染的程度是由HA决定的。在自然感染中，不活跃的HA由一种或多种胰蛋白酶样、精氨酸特异性内切酶在支气管上皮细胞分泌而成熟到细胞外的HA1和HA2。HA蛋白是二硫键连接的HA1-HA2同质三聚体。它在宿主范围限制和毒力测定中也起着重要的作用。血凝素和/或神经氨酸酶基因的遗传变异导致新流感菌株的出现。