FITC标记的谷氨酸受体相互作用蛋白2抗体
产品名称： FITC标记的谷氨酸受体相互作用蛋白2抗体
英文名称： Anti-GRIP2/FITC
产品编号： HZ-20140R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GRIP2/FITC Conjugated antibody
FITC标记的谷氨酸受体相互作用蛋白2抗体
| 英文名称 | Anti-GRIP2/FITC |
| 中文名称 | FITC标记的谷氨酸受体相互作用蛋白2抗体 |
| 别 名 | Glutamate receptor-interacting protein 2; GRIP-2; GRIP2_HUMAN; GRIP2; KIAA1719. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 112kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from rat GRIP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. The glutamate receptor interacting proteins, GRIP1 and GRIP2, are members of the PDZ domain-containing protein family, and they specifically bind to the carboxy-terminus of AMPA receptor subunits, GluR-2 and GluR-3. GRIP1 and GRIP2 are involved in the targeting of GluR-2 and GluR-3 to the synapse. GRIP1 and GRIP2 are widely expressed in brain, with the highest levels in the cerebral cortex, hippocampus and olfactory bulb. They are both enriched in synaptic plasma and postsynaptic density fractions. GRIP1 is expressed in early development before the expression of AMPA receptors, specifically postnatal days 8-10, while GRIP2 expression parallels that of AMPA receptors during later developmental stages. GRIP1 and GRIP2 may mediate the endocytotic rate of GluR-2 and GluR-3 in response to the phosphorylation of the receptors on Ser 880 by PKC, which is implicated in the induction of cerebellar long-term depression (LTD). Function: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Subunit: Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the C-terminal tail of PRLHR. Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Similarity: Belongs to the GRIP2 family. Contains 7 PDZ (DHR) domains. Database links: Entrez Gene: 80852 Human Entrez Gene: 509537 Cow Entrez Gene: 484638 Dog Entrez Gene: 243547 Mouse Entrez Gene: 171571 Rat SwissProt: Q9C0E4 Human SwissProt: Q9WTW1 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
谷氨酸受体介导大脑中最兴奋的神经传递，在神经可塑性、神经发育和神经退行性变中起重要作用。谷氨酸受体相互作用蛋白GRIP1和GRIP2是PDZ结构域蛋白家族的成员，它们与AMPA受体亚基GluR-2和GluR-3的羧基端特异性结合。GRIP1和GRIP2参与GluR-2和GluR-3对突触的靶向作用。GRIP1和GRIP2在大脑中广泛表达，在大脑皮质、海马和嗅球中表达最高。它们都富含突触血浆和突触后密度分数。GRIP1在AMPA受体表达之前的早期发育中表达，特别是出生后8-10天，而GRIP2的表达与AMPA受体在发育后期的表达相似。GRIP1和GRIP2可能介导GluR-2和GluR-3对PKC诱导的Ser 880受体磷酸化的内吞作用，这可能与小脑长期抑郁（.）的诱导有关。