Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. *   http://www.creative-diagnostics.com/Anti-MED22-PAb-198473-147.htm