TSC2 polyclonal antibody
产品名称： TSC2 polyclonal antibody
英文名称： TSC2 polyclonal antibody
产品编号： PAB16994
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TSC2.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S1254 of human TSC2.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody detects endogenous levels of total TSC2 protein.
- Form:
- Liquid
- Storage Buffer:
- In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL.J Cell Biol. 2006 Apr 24;173(2):279-89.
- 2.
- Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J.Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94. Epub 2004 Sep 1.
- 3.
- The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Li Y, Inoki K, Vacratsis P, Guan KL.J Biol Chem. 2003 Apr 18;278(16):13663-71. Epub 2003 Feb 11.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- ELISA
- Entrez GeneID:
- 7249
- Protein Accession#:
- P49815
- Gene Name:
- TSC2
- Gene Alias:
- FLJ43106,LAM,TSC4
- Gene Description:
- tuberous sclerosis 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- tuberin
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