FITC标记的β3肾上腺素能受体抗体
产品名称： FITC标记的β3肾上腺素能受体抗体
英文名称： Anti-beta 3 Adrenergic Receptor/FITC
产品编号： HZ-1063R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-beta 3 Adrenergic Receptor/FITC Conjugated antibody
FITC标记的β3肾上腺素能受体抗体
| 英文名称 | Anti-beta 3 Adrenergic Receptor/FITC |
| 中文名称 | FITC标记的β3肾上腺素能受体抗体 |
| 别 名 | beta3-adrenergic receptor; beta3-AR; adrenergic; beta-3- receptor; ADR B3; ADRB 3; ADRB3; ADRB3R; Adrenergic beta 3 receptor; B3AR; Beta 3 adrenoceptor; Beta 3 adrenoreceptor; Beta 3AR; B3AR; BETA3AR; ADRB3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 神经生物学 生长因子和激素 细胞膜受体 内分泌病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADRB3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: beta 3 Adrenergic Receptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epenephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins. beta 3 Adrenergic Receptor expression has been documented in adipose tissues, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of this protein. Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed mainly in adipose tissues. Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. Database links: Entrez Gene: 155 Human Entrez Gene: 11556 Mouse Entrez Gene: 25645 Rat SwissProt: P13945 Human SwissProt: P25962 Mouse SwissProt: P26255 Rat Unigene: 2549 Human Unigene: 278475 Mouse Unigene: 10100 Rat Omim: 109691 HumanImportant Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ARβ3是新近发现的,继β1和β2之后的第3个β型肾上腺素受体亚型.分子量：44KDa(404AA) 近年来研究表明:β3-肾上腺素受体该受体基因突变或基因多态性与机体肥胖及心血管疾病相关;心力衰竭时该受体的含量明显增加,β3肾上腺素能受体与心血管疾病的相关研究可能为心血管疾病的预测、防治的新方法 |
β3肾上腺素能受体主要分布在脂肪组织中，参与脂肪分解和产热的调节。β肾上腺素能受体参与肾上腺素和去甲肾上腺素诱导的腺苷酸环化酶的激活。β3肾上腺素能受体在脂肪组织、心脏和消化道和泌尿道器官(膀胱、结肠、小肠、胃、输尿管)的平滑肌中有表达。利用替代启动子和/或3-质粒非翻译区可导致该蛋白表达的组织特异性调节。