FITC标记的F-box蛋白家族FBXO25抗体
产品名称： FITC标记的F-box蛋白家族FBXO25抗体
英文名称： Anti-FBXO25/FITC
产品编号： HZ-8491R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-FBXO25/FITC Conjugated antibody
FITC标记的F-box蛋白家族FBXO25抗体
| 产品编号 | bs-8491R-FITC |
| 英文名称 | Anti-FBXO25/FITC |
| 中文名称 | FITC标记的F-box蛋白家族FBXO25抗体 |
| 别 名 | F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25; MGC20256; MGC51975; OTTHUMP00000115399; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXO25 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FBXO25 is a member of the F box protein family which is characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1 cullin F box), which function in phosphorylation dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD 40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein protein interaction modules or no recognizable motifs. FBXO25 belongs to the Fbxs class. There are three named isoforms produced by alternative splicing. FBXO25, also known as FBX25, is a 367 amino acid protein that contains one C-terminal F-box domain and belongs to the Fbx class of the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Expressed at high levels in brain, FBXO25 localizes predominantly to the nucleus and directly interacts with Skp1 p19 and CUL-1. Disruption of the gene encoding FBXO25 can lead to X-linked mental retardation. Function: Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ)protein huntingtin (HTT) (By similarity). Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complexconsisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly withSKP1 and CUL1. Interacts (via C-terminus) with beta-actin (viaN-terminus). Subcellular Location: Nuclear. Note=In the nucleus, associateswith a subnuclear dot-like structure. Colocalized with SKP1 Tissue Specificity: Expressed in all brain tissue observed. DISEASE: Note=A chromosomal aberration involving FBXO25 is a causeof X-linked mental retardation (XLMR). Translocationt(X;8)(p11.22;p23.3) with SHROOM4. Similarity: Contains 1 F-box domain. Database links: Entrez Gene: 26260 Human Entrez Gene: 66822 Mouse Entrez Gene: 364637 Rat Omim: 609098 Human SwissProt: Q1RMS8 Cow SwissProt: Q8TCJ0 Human SwissProt: Q9D2Y6 Mouse SwissProt: Q641X7 Rat Unigene: 438454 Human Unigene: 37950 Mouse Unigene: 3663 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
FBXO25是F盒蛋白家族的成员，其特征在于约40个氨基酸基序，F盒。F盒蛋白是泛素蛋白连接酶复合物（SCFs）（Skp1 Culrin F盒）的四个亚基之一，其功能依赖于磷酸化依赖泛素化。F盒蛋白被分为3类：含有WD 40结构域的FBWs，含有富含亮氨酸重复序列的FBLs，和含有不同蛋白质-蛋白质相互作用模块或没有可识别基序的FBXs。FBXO25属于FBXS级。有三个命名的异构体产生的选择性剪接。