FITC标记的鞘氨醇激酶2抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的鞘氨醇激酶2抗体

FITC标记的鞘氨醇激酶2抗体

商家询价

产品名称: FITC标记的鞘氨醇激酶2抗体

英文名称: Anti-SPHK2/FITC

产品编号: HZ-7598R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: IF=1:50-200

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 Rabbit Anti-SPHK2/FITC Conjugated antibody 

FITC标记的鞘氨醇激酶2抗体

 

英文名称 Anti-SPHK2/FITC
中文名称 FITC标记的鞘氨醇激酶2抗体
别    名 sphingosine kinase 2; SK 2; SPK 2; C76851; MGC102297; SPHK2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  细胞凋亡  转录调节因子  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 72kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPHK2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq].

Function:
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.

Subcellular Location:
Isoform 1: Cytoplasm. Membrane. Isoform 2: Lysosome membrane.

Similarity:
Contains 1 DAGKc domain.

Database links:

Entrez Gene: 56848 Human

Entrez Gene: 56632 Mouse

Omim: 607092 Human

SwissProt: Q9NRA0 Human

SwissProt: Q9JIA7 Mouse

Unigene: 528006 Human

Unigene: 24222 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application

该基因编码磷酸鞘氨醇磷酸化为鞘氨醇-1-磷酸,这涉及细胞分化,运动性和细胞凋亡。编码的蛋白在维持鞘氨醇-1-磷酸的细胞水平中起作用。该基因产物还可增强不同细胞类型的细胞凋亡并抑制细胞增殖。在肥大细胞中,编码的蛋白质是必需的钙,蛋白激酶C激活和细胞因子的产生和脱颗粒的涌入。选择性剪接导致多个转录变体。[由RefSeq提供]。