FITC标记的鞘氨醇激酶2抗体
产品名称: FITC标记的鞘氨醇激酶2抗体
英文名称: Anti-SPHK2/FITC
产品编号: HZ-7598R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
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Rabbit Anti-SPHK2/FITC Conjugated antibody
FITC标记的鞘氨醇激酶2抗体
英文名称 | Anti-SPHK2/FITC |
中文名称 | FITC标记的鞘氨醇激酶2抗体 |
别 名 | sphingosine kinase 2; SK 2; SPK 2; C76851; MGC102297; SPHK2_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 72kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SPHK2 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. Subcellular Location: Isoform 1: Cytoplasm. Membrane. Isoform 2: Lysosome membrane. Similarity: Contains 1 DAGKc domain. Database links: Entrez Gene: 56848 Human Entrez Gene: 56632 Mouse Omim: 607092 Human SwissProt: Q9NRA0 Human SwissProt: Q9JIA7 Mouse Unigene: 528006 Human Unigene: 24222 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因编码磷酸鞘氨醇磷酸化为鞘氨醇-1-磷酸,这涉及细胞分化,运动性和细胞凋亡。编码的蛋白在维持鞘氨醇-1-磷酸的细胞水平中起作用。该基因产物还可增强不同细胞类型的细胞凋亡并抑制细胞增殖。在肥大细胞中,编码的蛋白质是必需的钙,蛋白激酶C激活和细胞因子的产生和脱颗粒的涌入。选择性剪接导致多个转录变体。[由RefSeq提供]。