FITC标记的少突胶质细胞髓鞘相关蛋白抗体
产品名称： FITC标记的少突胶质细胞髓鞘相关蛋白抗体
英文名称： Anti-MOBP/FITC
产品编号： HZ-11184R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MOBP/FITC Conjugated antibody
FITC标记的少突胶质细胞髓鞘相关蛋白抗体
| 产品编号 | bs-11184R-FITC |
| 英文名称 | Anti-MOBP/FITC |
| 中文名称 | FITC标记的少突胶质细胞髓鞘相关蛋白抗体 |
| 别 名 | MGC87379; Myelin associated oligodendrocyte basic protein; MOBP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MOBP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The gene encoding MOBP a member of the central nervous system myelin-constituting proteins, maps to chromosome 3p22.2. MOBP has many splice variants that share a 68 amino acid N-terminal domain. MOBP-71, MOBP-81A, MOBP-99, and MOBP-169 are MOBP splice variants that contain exon 8b, which is similar to myelin basic protein (MBP) mRNA RTS, however MOBP-69, MOBP-81B, and MOBP-170 lack this exon. The splice variants that contain exon 8b are expressed in myelin, while those lacking exon 8b are retained in the oligodendrocyte soma. Exon 8b-containing variants are directed to sites of myelin sheath assembly by exon 8b, where they play a structural role in myelin formation. Splice variants lacking exon 8b likely play a cellular and/or regulatory role. MOBP is implicated in multiple sclerosis (MS), a human demyelinating disease, and in allergic encephalomyelitis in rodents. Function: MOBP (Myelin-associated oligodendrocytic basic protein) is abundantly expressed specifically in oligodendrocytes and is the third most abundant protein in CNS myelin. MOBP is present in the major dense line of CNS myelin suggesting a role in the compaction or stabilization of myelin. Subcellular Location: Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin (By similarity). Database links: UniProtKB/Swiss-Prot: Q13875.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
编码MUBP的中枢神经系统髓鞘构成蛋白的基因，映射到染色体3P2.2.2。MOBP有许多剪接变异体，共有68个氨基酸的N-末端结构域。MOPP-61、MOBP-81A、MOBP99和MOBP169是含有外显子8B的MUMP剪接变异体，其类似于髓鞘碱性蛋白（MBP）mRNA RTS，然而MUBP－69、MUCP-81B和MUBP170缺乏此外显子。包含外显子8B的剪接变异体在髓鞘中表达，而缺少外显子8B的剪接变异体被保留在少突胶质细胞瘤中。含有变异体的外显子8B定向于外显子8B的髓鞘组装部位，在髓鞘形成中起着结构作用。剪接变异体缺乏外显子8B可能发挥细胞和/或调节作用。MAMP与多发性硬化症（MS）、人类脱髓鞘疾病和啮齿动物变态反应性脑脊髓炎有关。